18th October 2022

Investigating protein solution dynamics using XPCS at an XFEL

Novel experiment opens up possibility of studying collective dynamics providing insight for better drug... (Read more)
11th March 2022
Figure 2: Membrane deformations induced by actin assembly. A membrane bilayer (pink) constituting an initially spherical liposome is deformed through the growth of a branched actin network (blue marks the colour of the end of actin filaments) at its surface. Spikes (inward) and tubes (outward) are formed during this process. Note that compared to the cell geometry, the geometry here is inside out, as the ingredients of the cytoskeleton are outside the liposome. Bar 5 μm. Copyright: Cécile Sykes, CNRS

How Active Biopolymer Networks Shape the Cell Membrane

Experiments on active deformations of a cell membrane by an actin assembly may inspire new materials and approaches. Cécile Sykes from the Laboratoire de Physique de l‘Ecole Normale Supérieure reports on results raising... (Read more)
20th October 2021
Schematic representation of our modelling pipeline. A neural network trained with an ensemble of protein conformations learns an internal model of their conformational space. This model can then be interrogated to generate new, plausible conformations. Copyright: Durham University

Sampling Protein Conformational Space

Scientists at Durham University, UK, present an approach for the prediction of intermediate protein... (Read more)
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