6th February 2025
Figure 1: Aspect ratio is a crucial network building block property, defining network formation, architecture, and mechanics in synthetic and living systems. (Left) Schematic representation of the aspect ratios (AR) of protein L polyprotein constructs and fibrin proto-fibers. (Middle) A schematic representation of the two dominated formation regimes: translation diffusion limited (TDL) where building blocks can only interact by translating their centre of mass; and rotationally diffusion limited (RDL) where building blocks are able to interact purely via rotation about their centre of mass. (Right) The fitted increase in mechanical rigidity as a function of aspect ratio with inserted schematics showing the change in structural topology as the system transitions from TDL to RDL formation above the critical aspect ratio, ARc. Copyright: Image partly published in Hughes M. D. G. et al., Nat. Commun. 14, 5593 (2023) under a Creative Commons Attribution 4.0 International License.
6th February 2025

Biology Exploits Geometry

Impact of Aspect Ratio on Protein Network Assembly: Scientists at SoftComp partner University of Leeds and STFC Rutherford Appleton Laboratory, UK, have made an exciting discovery about the functional advantages of high aspect... (Read more)
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