We have an open postdoc position in the Division of Physical Chemistry at Lund University on the biophysical properties of antibody solutions and their investigation with a combination of scattering techniques and computer simulations.
Monoclonal antibodies (mAbs) are engineered proteins that can serve as substitute antibodies in the immune system. Due to their high potential in e.g. cancer treatment they attract enormous attention from the pharmaceutical industry. At the same time the formulation of high concentration injectable mAb biologics is very challenging as it is often severely limited due to high turbidity and/or high viscosity.
In this project we aim at establishing an approach to understand the origin of this behaviour and to predict it from low concentration data and mAb molecular structure. The postdoc we are looking for will apply a variety of static and dynamic scattering techniques (based on light and x-rays) on mAb samples, including static and dynamic light scattering (SLS/DLS), small-angle x-ray scattering (SAXS) and x-ray photon correlation spectroscopy (XPCS), and analyse the data. (S)he will also perform microrheology experiments, establish mAb phase/state diagrams and closely work together with simulators and theoreticians in a concerted effort towards a better understanding of the complex solution behaviour of mAbs.
Deadline for application is 4 May 2022
More information and a link for the on-line application can be found at: