1 year postdoc position within Spanish government project is based on a recent publications showing the importance of membrane tension for interaction of nanoparticles with cells (1–3). Deformation of cells and compression of lipid bilayers by strongly adsorbing nanoparticles is related to a non-chemical and non-biological mechanism of recently discovered antibacterial action of nanoparticles.

Responsibilities

Work with Molecular Dynamics, Langevin dynamics, numerical surface evolvers, as well as analytical theory based on the Helfrich model to investigate the interaction of idealized cell membrane models with nanoparticles of different geometries.
The effect of structure parameters such as size, topography, spikes, flexibility or rigidity of the material, surface properties, charge will be systematically evaluated.

Qualifications

· CUDA programming
· Molecular Dynamics of Soft Matter
· Monte Carlo simulations
· Theoretical physics
· Neural networks algorithms

References

(1) Fleury, J.-B.; Werner, M.; Guével, X. L.; Baulin, V. A. Protein Corona Modulates Interaction of Spiky Nanoparticles with Lipid Bilayers. J. Colloid Interface Sci. 2021, 603, 550–558. https://doi.org/10.1016/j.jcis.2021.06.047.
(2) Linklater, D. P.; Baulin, V. A.; Guével, X. L.; Fleury, J.-B.; Hanssen, E.; Nguyen, T. H. P.; Juodkazis, S.; Bryant, G.; Crawford, R. J.; Stoodley, P.; Ivanova, E. P. Antibacterial Action of Nanoparticles by Lethal Stretching of Bacterial Cell Membranes. Adv. Mater. 32 (52), e2005679. https://doi.org/10.1002/adma.202005679.
(3) Linklater, D. P.; Baulin, V. A.; Juodkazis, S.; Crawford, R. J.; Stoodley, P.; Ivanova, E. P. Mechano-Bactericidal Actions of Nanostructured Surfaces. Nat. Rev. Microbiol. 2020, 1–15. https://doi.org/10.1038/s41579-020-0414-z.